Spore, I think. My family got it for me and my brother back in 2008 or so. In terms of the first PC game I played, I'm not sure. My memory with their names is foggy, considering I was only 4 or 5 when I first used a computer, but I do recall seeing games/discs like the first Call of Duty and Age of Empires on the desk.
I'm not sure if that Spore disc works anymore, due to Maxis/EA's stupid 5 use code or whatever.